Tulsi Therapeutics, a startup incubated at ASPIRE-BioNEST,College of Hyderabad (UoH), has introduced the world’s first profitable animal trial of a novel stem cell–exosome mixture remedy for persistent liver failure.
| Photograph Credit score: Getty Photos/iStockphoto
Tulsi Therapeutics, a startup incubated at ASPIRE-BioNEST,College of Hyderabad (UoH), has introduced the world’s first profitable animal trial of a novel stem cell–exosome mixture remedy for persistent liver failure.
Power liver failure stays a severe public well being concern in India, contributing to almost 20% of worldwide liver-related deaths. With transplantation being the one present remedy, investigational product – ‘Tulsi-28X’ represents a possible paradigm shift. It really works by secreting regenerative proteins and development components, stimulating the restore of diseased liver tissue.
“We’re dedicated to creating world-class but inexpensive regenerative options. Our subsequent step is to take Tulsi-28X into human medical trials in collaboration with Nizam’s Institute of Medical Sciences (NIMS),” mentioned Tulsi Therapeutics chief scientific officer Ravi Bonthala.
The preclinical trial, carried out in collaboration with international specialists together with Indiana College, (USA) Naga Chalasani and PGIMER, (Chandigarh) Ajay Duseja had demonstrated 100% of the animals handled with ‘Tulsi-28x’ confirmed reversal of liver fibrosis (indicating liver regeneration) leading to zero deaths, in comparison with solely 14% reversal (p<0.001) and 43% deaths (p<0.0066) within the untreated management group, in keeping with a press launch on Thursday.
Whereas conceptualized in america, the platform was solely developed in India by three years of intensive analysis at ASPIRE-BioNEST. “It is a important milestone for India’s biotech trade. ASPIRE-BioNEST supplied a world-class platform that helped us translate our imaginative and prescient into scientific actuality. Whereas human trials are the subsequent problem, this research opens doorways to a brand new class of biologics in liver illness,” mentioned founder & CEO of Tulsi Therapeutics Sairam Atluri.
Key outcomes had been introduced on the AASLD 2024 Liver Convention in San Diego (US) and accepted for publication within the ‘Journal of Regenerative Drugs’.The agency may be the primary biotech firm creating twin stem cell–exosome biologic. It’s mentioned to be a first-in-class regenerative remedy derived from Wharton’s Jelly mesenchymal stem cells and their native exosomes—a mixture by no means earlier than examined in any animal mannequin worldwide.
“This milestone highlights how India’s innovation ecosystem—anchored by establishments just like the UoH and enabled by BIRAC and incubators like ASPIRE-BioNEST—is able to delivering breakthrough international biotech merchandise,” mentioned Vice Chancellor B.J. Rao.
“The achievement is a proud second for all of us at ASPIRE-BioNEST. It displays our mission to nurture science-led innovation with real-world influence. it’s extremely fulfilling to see this ecosystem help a global-first breakthrough in regenerative medication,”mentioned CEO of ASPIRE-BioNEST Anil Kondreddy.
ASPIRE-BioNEST supported by BIRAC, Division of Biotechnology, mentors early-stage biotech startups by infrastructure and funding entry. It has supported greater than 75 deep-tech life sciences startups and was acknowledged as “Finest Rising Bio-Incubator” by BIRAC in 2021, added the discharge.
Printed – July 24, 2025 04:34 pm IST
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